Endocrine Abstracts

Vitamin D receptor (VDR) and its ligand 1,25-Dihydroxyvitamin D3 (1,25OHD3) play, in general, an inhibitory role on the growth of normal and malignant cells. However, the mechanisms for this anti-proliferative action remain not completely understood. Recently, a 1,25OHD3-mediated effect on hormone production and steroidogenic genes has been reported in the human steroid-secreting adrenocortical cancer cell line NCI-H295R (Lundqvist J et al. 2010). The aim of this study ...